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Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose
Patients were to be randomized to 1200 mg, 450 mg, or placebo, administered intravenously daily for 3 days followed by weekly for 4 weeks
Compounded formulations are not interchangeable with prescription drugs
If weight loss has plateaued or side effects are limiting progress, your clinician can evaluate whether a dosing adjustment or broader treatment plan modification is appropriate
You might be low in vitamin B12, a nutrient your body needs to keep your brain sharp, your energy steady, and your nerves healthy
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