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His colleague Shin-ichiro Imai, a professor of developmental biology at the Washington University School of Medicine who first met Sinclair in Guarentes lab, says Sinclair had a keen eye for capturing novel concepts and, based on that foundation, building new lines of research faster than anyone else. At the time, aging research, once considered a fringe science, was still in its infancy, but Sinclair was determined to propel it to legitimacy

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They also reported that these patients had higher levels of interleukin 1 (IL-1), IL-6, and TNF- , suggesting an inflammatory state and oxidative stress in migraine patients (112)

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Clin Endocrinol (Oxf) (2013) 78:15564