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In addition, it is demonstrated that the inhibition of autophagy-mediated HDAC enhances HMGB1 acetylation, consequently releasing HMGB1 in ferroptosis

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During the catabolism of fatty acids with an odd number of carbon atoms and the amino acids valine, isoleucine, methionine, and threonine, the resultant propionyl-CoA is converted to succinyl-CoA for oxidation in the TCA cycle