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50 Local SDF-1 release increased the recruitment of systemically infused bone marrow-derived MSCs by 700% in a mouse model of myocardial infarction (MI), 51 suggesting that cartilage repair scaffolds releasing SDF-1 may perform synergistically with MSCs from marrow recruitment or intra-articular injections

In addition, Lactobacillus can produce indole-3-aldehyde, which acts on aryl hydrocarbon receptor (AhR) and activates leukocytes

Other potential risk of the HGF/c-Met inhibition by the systemic treatment is in affecting the tissue regeneration and damage repair processes in patients, although we did not observe any side effects on our mouse models upon SU11274 administration