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In a 2023 study [57], PD was induced in mice via MPTP administration, followed by eight weeks of KD feeding

However, early attempts to apply rotenone as a PD model found that high doses of rotenone induce widespread brain damage rather than specifically targeting the nigrostriatal system, which might interfere with the value of relevant studies (Heikkila et al., 1985

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Biochem J 30:14461461 Hossain MA, Nakano Y, Asada K (1984) Monodehydroascorbate reductase in spinach chloroplasts and its participation in regeneration of ascorbate for scavenging hydrogen peroxide

Sun QA, Kirnarsky L, Sherman S, Gladyshev VN