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They release a cocktail of signaling molecules including TNF-alpha, interleukin-1, interleukin-6, bone morphogenetic proteins (BMPs), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-beta), and vascular endothelial growth factor (VEGF)

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However, IL-1Ra treatment was not associated with improvements in knee pain, function, stiffness, or cartilage turnover (239)

Cooper AJL, Pulsinelli WA, Duffy TE

Because there are so many complicating factors, it's crucial to work with a healthcare provider who can evaluate your results in the context of your current symptoms and medical history and help create an effective, personalized plan