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Dysfunction of VSMCs represents a key pathological basis and an important contributor to vascular diseases

About this compound FOXO4-DRI is studied in laboratory settings as a synthetic research peptide

This could well account for the energy failure and widespread mitochondrial dysfunction previously observed in aspirin-treated MnSOD-deficient yeast cells, as indicated by a decreased respiratory rate, disrupted mitochondrial membrane potential, and release of cytochrome c 20