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Serine and glycine are the major sources of carbon units to the one-carbon metabolism, being involved in the synthesis of nucleotides [16, 29]

Glutathione coated spherical AuNPs (G-AuNPs) have been extensively investigated as drug delivery system because of their low affinity to serum proteins 20 : they are photoluminescent and exhibit size independent emission at 600 nm and 800 nm when excited at 396 nm and 350 nm, respectively

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Hence, metabolizing and scavenging systems to remove them are functionally critical and tightly controlled in the cell