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A phase 3, randomized, multi-center, open-label study of trastuzumab deruxtecan (T-DXd) versus investigators choice chemotherapy in HER2-low, hormone receptor positive breast cancer patients whose disease has progressed on endocrine therapy in the metastatic setting (DESTINY-Breast06)

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quantified 4,405 proteins in murine hepatic organoids and observed differentiation-dependent upregulation of CYP450 enzymes, hepatic transporters, and other metabolic proteins, which parallels our observations in human iHLOs 14

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Use the medication in defined periods, maintain with lifestyle between cycles

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