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The rate of change during this phase depends heavily on baseline body composition, caloric intake, activity level, and adherence to protocol

Nitric oxide (NO), a reactive nitrogen species, acts as a signaling molecule that modulates vasodilation and neurotransmission [4, 5]

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In mammalian systems, hm 5 C levels exhibit marked spatial heterogeneity, as demonstrated in the mouse brain [182]: High hm 5 C concentrations were identified in the brainstem, hippocampus, and cerebellum, while the hypothalamus and amygdala showed moderate levels, and the cerebral cortex displayed the lowest density