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While it remains unsettled as to what proportion of creatine within the fetal brain is imported versus synthesis natively, it is clear that this small molecule plays an integral part in ongoing neurodevelopment ( Clinically, patients with CCDS exhibit a combination of developmental delay particularly in expressive language, ID, and autistic behaviors ( Other IEMs have been associated with an increased incidence of ASD

According to Medscape, 0.5% to 2% of people worldwide suffer from the disorder

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