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Chronic joint/tendon issues: 68 weeks may be appropriate

Vegetarian and Vegan Support: Individuals following a vegetarian or vegan lifestyle often struggle to obtain sufficient B12 from diet alone

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Split dosing may help if: single morning dose produces effects that fade by afternoon, you are using higher doses (450-500mcg) where sustained levels may help, or evening administration fits your schedule better than early morning

Inflammatory blockade restores adult hippocampal neurogenesis