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10.1016/s0140-6736(17)31046-2 [DOI] [PMC free article] [PubMed] [Google Scholar] Emberson J

Through -glucuronidase activity, gut microbes deconjugate bound androgens, increasing circulating free testosterone levels ( Clinically, PCOS patients exhibit reduced gut microbial -diversity, an elevated Bacteroidetes-to-Firmicutes ratio, and decreased abundance of beneficial bacteria such as Akkermansia muciniphila

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Nitrogen-containing heterocycles are abundant in nature and are found in many natural products such as alkaloids, vitamin derivatives, antibiotics, and hormones

More alarming still are reports of users contracting HIV, hepatitis B and C, and serious eye infections from contaminated injections