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However, in 4 randomized, placebo-controlled trials, migraine aura was only reported in 1 (2%) of 61 participants who received placebo infusion (isotonic saline) (Fig

An analytical study based on post-marketing approval pharmacovigilance data

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Funding Japan Society for the Promotion of Science, 23K13614, 23H01771, Japan Agency for Medical Research and Development, 23bm1123031h0001, Takeda Science Foundation, Mochida Memorial Foundation for Medical and Pharmaceutical Research, Kanagawa Institute of Industrial Science and Technology

Using it past this date introduces an unacceptable variable into your research, even if the water appears clear