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Through its activation of the phosphoinositol-3 kinase pathway and phosphorylation of the X-linked inhibitor of apoptosis protein (XIAP), IGF-1 acts to protect Kpffer cells and counter the potentially lethal effects of sepsis

Its objective is to counteract pathologies caused by iron imbalance, such as: iron deficiency anemia, imbalance of Iron Ion (from ferrous to ferric and from ferric to ferrous)

Hyperpolarization resulting from this mechanism will result in deactivation of voltage-dependent Ca channels, resulting in decreased Ca influx, which will favor smooth muscle relaxation

Dorsal root ganglion (DRG) neurons play an important role in the painful NP

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