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Some individuals experience minor improvements in their dizziness and weakness

Those flat dark spots are essentially excess melanin triggered by inflammation, and they can persist for weeks or months

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Current experiments rely on FXN-knockdown cells or YG8s mouse models, which do not replicate heterogeneity in GAA repeat expansion length observed in patients (a factor strongly correlated with disease severity) and do not evaluate organ-targeting efficiency or long-term safety of ferroptosis inhibitors such as deferiproneparticularly whether simultaneous delivery to cerebellum and heart is achievable and whether sustained treatment disrupts erythroid iron homeostasis and induces anemia

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