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MSCs also inhibit the production of proinflammatory cytokines (TNF-, IL-1 and iNOS), macrophage activation and neutrophil recruitment and promote anti-inflammatory cytokine secretion (IL-10), which is beneficial for recovery from liver injury and inflammatory responses (167)

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This dual modulation allows BPC-157 to normalize nitric oxide levels whether they are pathologically elevated or depleted, providing adaptive vascular protection

Mol Cell Biochem (2014) 386:7383

GSH synthesis is catalyzed by glutamate cysteine ligase (GCL, previously known as GCS) and GSH synthetase