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232 Moisturizers, such as gels with hyaluronic acid or polycarbophil, improve tissue hydration and may provide a longer duration of relief from vulvovaginal irritation

VC enhances the cytotoxic activity of adoptively transferred CD8 T cells, and also co-operates with immune checkpoint therapy (ICT) in many cancer types, proving that a combination of VC and ICT can be curative in models of mismatch repair deficient tumors with high mutational burden

An alternative interpretation could be that GH stimulates local muscle IGF-I release, which subsequently acts in an autocrine/paracrine manner

Ongoing registrational trials, many of which now incorporate fertility biomarkers as secondary end-points, will ultimately determine whether these large molecules can deliver durable cancer control without sacrificing reproductive potential in an era of increasingly personalised onco-fertility care