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As an addictive substance, nicotine not only functions in the central nervous system but also affects non-neuronal cells via binding to its receptor, resulting in the promotion of cell survival or enhancement of chemoresistance (Guo et al, 2008

Federal policies stripped access to traditional tobacco and devastated American Indian communities American Indians have faced historical trauma, forced assimilation efforts, and several forms of genocide that continue to negatively affect their health

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[32] Frenchman Jean Nicot (from whose name the word nicotine is derived) introduced tobacco to France in 1560, and tobacco then spread to England