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demonstrated that in dendritic cells (DCs), LPS-induced glycolysis is repurposed to replenish citrate, an intermediate metabolite in the TCA cycle that is depleted for the de novo synthesis of fatty acids ( 2 ( de novo lipogenesis is important for phagocytosis as it requires ongoing lipid synthesis in the ER for membrane expansion, such that Ms can surround and capture targeted pathogens for internalization ( de novo lipogenesis, an anabolic process that is NADPH-dependent, in regulating the inflammatory response of myeloid cells

Despite this miniature size it has an extremely broad effect at the cellular level, it modulates the expression of more than 4,000 human genes (Pickart & Margolina 2012)

Additionally, protein interaction network analysis is widely used for target screening