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Despite these protective mechanisms, elevated serum B12 levels (hypercobalaminaemia) can occur and may indicate underlying health conditions rather than simple overconsumption

Institutional research settings that track NAD+ levels and methylnicotinamide excretion often find individual dose-response variability of 3040%, meaning the 'right' dose for one subject may be subtherapeutic or excessive for another

10.1182/blood-2008-03-040253 [DOI] [PMC free article] [PubMed] [Google Scholar] Carmel R., Sarrai M