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We then fit lowess smoothed curves for the association between age of smoking onset and mean GPH and GMH, to determine if there was a similar dose-response curve to COPD prevalence (Supplementary file Figure 2)

Oxidative stress can rise from smoking tobacco, exposure to pollution, radiation and even ultraviolet rays

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By contrast, in e-cigarettes, either nicotine derived from tobacco or synthetic nicotine* is added to the e-liquid (also known as vape juice) used in the product