Discussion Previous studies have reported that the most frequently observed AEs associated with dICIs were predominantly dermatological (34% for any grade and 4.2% for grade 3 or higher), endocrine (23.8% for any grade and 4.2% for grade 3 or higher), gastrointestinal (18.2% for any grade and 2.4% for grade 3 or higher), and hepatic (15.8% for any grade and 8.2% for grade 3 or higher) ( Khoja et al
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The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
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Another study showed that supplementation with GSH was able to stabilize the cytokine disparity in other viral diseases, which effectively mitigated inflammation patients with concomitant HIV and pulmonary TB [58]
