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Although OA pathogenesis is exceedingly complex, recent studies underscore the multifactorial nature of the disease, involving mechanical overload, inflammatory responses, metabolic abnormalities, and cell death ( Cartilage deterioration and subchondral bone remodeling are hallmarks of OA

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All agents discussed in this section are shown in Figure 6B

Compared with traditional imaging or blood biochemical tests, oral microbiome analysis is not only non-invasive and easily repeatable, but also reflects microecological changes and underlying mechanisms of disease, offering new perspectives for personalized disease prevention and treatment

16 Dysregulated mitochondrial ROS production is a feature of smokers with COPD 17,18 that is not limited to the lungs