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In the United States, PMIs request to the Food and Drug Administration to market IQOS as a reduced risk product was condemned in January by the scientific panel advising the agency, which said the company had not conclusively proved IQOS use would result in less disease

Research conducted at the National Cancer Institute of Sri Lanka (Apeksha Hospital) (PMCID: PMC9810316, PMID: 36172654) found that individuals smoking two packs or more per day had twice the risk compared to those smoking one to two packs daily

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