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Monocytes from PASC patients with ongoing fatigue show a sustained reduction of prostaglandin-generating enzyme, the cyclooxygenase 2 (COX-2) 219

For instance, both the expression of Ogt and the level of O-GlcNAcylation are lower in the hippocampus of aged mice compared to young mice, resulting in impaired cognitive function in aged animals, and enhancing neuronal O-GlcNAcylation could potentially improve cognitive function [34]

Sodium-glucose co-transporter 2 (SGLT2) is a high-capacity/low affinity sodium-glucose cotransporter present in the apical membrane of proximal convoluted tubule cells (Vallon et al., 2011)