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Aberrant lipid metabolism in HCC generally manifests as alternations in lipid uptake and efflux, dysregulated endogenous lipid synthesis, elevated cholesterol esterification, and disruptions in lipid oxidation

In contrast, in ethanol-exposed Grx1 -deficient mice, accumulation of FAS-SSG drives hepatocyte apoptosis through dysregulation of NF-B and AKT serine/threonine kinase 1 (AKT1) signaling 47

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(2018) Single-cell RT-PCR in microfluidic droplets with integrated chemical lysis Anal