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Interestingly, DepB Rleg can reduce 3-keto-DON to 3- epi -DON with NADH, albeit with a catalytic efficiency 40-fold lower than with NADPH (Abraham et al., 2022)

These simple, short-term limits help healing and reduce the chance of prolonged discomfort

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In vitro and mechanistic studies (weakest for clinical conclusions) Cell culture studies showing peptides protecting retinal cells from various insults (oxidative stress, glucose toxicity, inflammatory cytokines, hypoxia)