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Research Findings Research on the cagrilintidesemaglutide combination has rapidly expanded since initial pharmacology studies established that the two peptides could be co-administered safely and produced additive effects on weight and glycemia

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In this context, differential tryptophan metabolism depending on astrocyte or microglia predominance determines the balance between tryptophan catabolites, such as neuroprotective kynurenic acid and pro-inflammatory quinolinic acid (27)