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More recently, osmotic pressure has been suggested to induce the systemic apoplastic release of signaling molecules like Glu 15

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doi: 10.1016/j.jaut.2021.102738 60 YamamotoKMashibaTTakanoKSuzukiTKamiMTakitaMet al

Despite the extensive evidence of prostate tumor interactions within the bone cavity, specific bone-targeted therapies have been unsuccessful in improving patient survival requiring a need for other therapeutic options for patients with bone metastatic disease [5]