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In the 1860s, the first cigarette factories were established in which tobacco was prepared by machine and rolled into cigarettes

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A randomized clinical trial reported that patients with PAD with active smoking who received the intensive intervention (physician advice, smoking cessation counseling, and pharmacologic treatment) had 21.3% rate of 6-month abstinence as compared to 6.8% in the less intensive treatment group who only received verbal advice to quit smoking (57)

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