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SAM is an essential cofactor in the pathway of synthesis of epinephrine, which is involved in learning processes and memory consolidation [29, 30]

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A broad inflammatory response and severe myelin distortion resulting from such anomalies might result in an immunological response in the CNS analogous to the pathophysiological circumstances of multiple sclerosis

As you get older, the systems that rely on NAD+ (like energy production, cognitive function, skin repair, immune health, and inflammation regulation) start to slow down, and declining NAD+ levels appear to be a key driver behind that slowdown