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It also inhibits ferroptosis by lowering intracellular iron and ROS levels, increasing GPX4 expression, and reducing ACSL4

The mitochondrial thioredoxin reductase system (TrxR2) in vascular endothelium controls peroxynitrite levels and tissue integrity

These results suggest that the severe fluctuations in calcium signaling increase the susceptibility of substantia nigra neurons to damage and cell death