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A translational review on NNMT inhibitor clinical development ( Emerging opportunities for NNMT inhibitor clinical translation , ScienceDirect, 2026) points out that alternative routes like polyamine biosynthesis could compensate for the raised SAM, and that partial rather than total inhibition might even be preferable specifically to avoid triggering those compensatory mechanisms from a chronically imbalanced SAM/SAH ratio

Research shows that targeting NNMT could help in treating these conditions by improving how the body uses energy, reducing fat, and bettering insulin sensitivity

It also plays a role in brain development and immune function

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