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Conversely, the ubiquitin ligase E3 HUWE1/MULE, which acts as a negative regulator of ferroptosis, regulates iron metabolism by targeting transferrin receptor 1 and counteracts abnormal iron accumulation, thereby alleviating acute liver injury caused by hepatic ischemia-reperfusion (I/R) [34]

Oxidative stress can lead to lipid peroxidation, a process in which ROS react with lipids in cell membranes, resulting in the formation of lipid peroxides and aldehydes such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) [9]

Additionally, correcting hypo-functioning thyroid, treating iron and zinc deficiency (and other documented macro and micronutrient deficiencies) also help ameliorate symptoms (94, 95)

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