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Dysbiosis of oral microbiota has been associated locally with periodontal, respiratory, cardiovascular and systemic cancers, including head and neck cancer [45], pancreatic cancer [46], and esophageal cancer [47], yet regarding factors that influence the oral microbiome composition are poorly understood

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by the 2000s, approximately 80% had first misused prescription opioids, reflecting how mass availability of a licit opioid created an entirely new gateway pathway

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PMC 6745078