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The intensity of a nicotine high depends on several variables: Amount of nicotine consumed Individual tolerance Method of delivery (vaping, smoking, nicotine pouches) Those who use nicotine frequently develop tolerance, causing them to use more to achieve the initial effects

A strength of the cohort is the availability of a comprehensive questionnaire and journal data on the participating women that allowed for the selection of healthy individuals with a healthy lifestyle and compensated for the imbalance of several observed confounders

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