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Oxidative Stress and the Cellular Need for Glutathione Support Modern life exposes individuals to unprecedented levels of oxidative stressors that deplete endogenous glutathione reserves

Lee, K.-A., Flores, R

Additional indicators of vitamin B12 deficiency can include difficulty maintaining balance, depression, confusion, dementia, poor memory, and soreness of the mouth or tongue

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on 24 patients with generalized vitiligo and 20 healthy controls found statistically significant higher levels of superoxide dismutase activity in erythrocytes, serum MDA, and nitric oxide (NO) and statistically significant lower levels of glutathione and glutathione peroxidase in the patients of vitiligo compared to the controls.[] Secondary to the oxidative stress, the polyunsaturated fatty acids undergo peroxidation resulting in formation of free radicals