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For instance, cancers resistant to poly (ADP-ribose) polymerase (PARP) inhibitors enhance base excision repair (BER) pathways to bypass senescence (Vickridge et al., 2022)

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Diaz Vivancos et al

Symptoms of deficiencyfatigue, weakness, paraesthesia, cognitive impairment, and mood disturbancestypically improve significantly with appropriate replacement therapy