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This is reflected in increased plasma catecholamine levels and is maintained by a positive feedback loop between SNS activity and ROS (Middlekauff et al., 2014

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Campeny E, Lopez-Pelayo H, Nutt D, Blithikioti C, Oliveras C, Nuno L, Maldonado R, Florez G, Arias F, Fernandez-Artamendi S, et al