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Costas says that additional evidence is needed, especially considering that the authors declare a conflict of interest, as many are shareholders or employees of a pharmaceutical company and owners of a patent on this gene. Miguel Barrueco, former head of the pulmonology department at the Hospital of Salamanca, takes the same cautious stance: he says the article is interesting, but it is advisable to be prudent in interpreting the results and not sow false therapeutic expectations, for example, about the short-term viability of a therapy for nicotine addiction like the one proposed. Similar studies conducted with other genes that also play a role in nicotine addiction have not resulted in their therapeutic applications