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[442] In particular, long-acting (for example, extended-release) injectable forms of buprenorphine have been shown to promote adherence to treatment while reducing the need for daily dosing, and to enhance patient-reported outcomes through improvements in quality of life, accessibility, social relationships, participation in employment, more flexible personal and professional schedules, and other treatment satisfaction measures

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Altered brain development: Long-term use can affect the structure and function of developing brains, leading to permanent changes in cognition and emotional regulation