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A nasal formulation of epinephrine (Neffy ) was FDA approved in 2024 for the emergency treatment of Type 1 allergic reactions, including anaphylaxis

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The finding that bretylium blocked nicotine-induced attenuation of the sustained response suggests that this attenuation was mediated by enhanced noradrenergic neurotransmission rather than by the inhibition of endothelial NO release, a postulated mechanism in other vascular beds (Hashimoto, 1994

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