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The pro-inflammatory cytokine interleukin (IL)-1 plays a vital role in the pathogenesis of OA by stimulation of specific signaling pathways like NF-B, PI3K/Akt, and MAPKs pathways

doi: 10.1016/j.immuni.2023.01.014 43 NakamizoSSugiuraYIshidaYUekiYYonekuraSTanizakiHet al

The results of that fairly routine clinical brain MRI/MRS scan piqued my interest because and here are the answers to your how? and why? questions above they revealed elevations of ventricular lactate similar to those that we had observed in patients with primary mitochondrial disorders, which I was investigating at the time as a Radiology faculty member at Columbia University Medical Center. Those increased lactate levels are basically synonymous with mitochondrial dysfunction We have found elevated ventricular lactate in nearly every disorder in which mitochondrial dysfunction has been implicated

Kohn, T

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