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Therefore, developing and validating biomarkers that directly indicate neuronal ferroptosissuch as specific oxidized phospholipid profiles, ferroptosis-related proteins (e.g., released HMGB1, modified GPX4), or their metabolic fragmentsis crucial for enhancing clinical diagnostic and therapeutic monitoring capabilities

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The practical implication: Cerebrolysin requires IV access, daily handling, and cannot be self-administered in non-clinical settings

5-10%