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The clinical manifestations of this disease range from asymptomatic neurocognitive dysfunction to mild neurocognitive disorder to full-blown HIV-associated dementia (Shapshak et al., 2011)

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Cigarette smoke causes direct injury to airway cells (Decramer et al., 2012) and may hasten the aging of lungs, thus accelerating the progression of COPD (Kazuhiro & Barnes, 2009)

Making it perfectly suitable for standard tube injectors or rolling machines