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of cleanlinesse, of modestie, men should not be ashamed, to sit tossing of Tobacco pipes and puffing of the smoke of Tobacco one to another, making the filthie smoke and stinke thereof, to exhale athwart the dishes, and infect the aire, when very often, men that abhorre it are at their repast? A CounterBlaste to Tobacco by King James I of England, 1604 King James I was ahead of his time

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Since cigarette smoking kills nearly half a million people in the U.S

The difference between this reduction in the combined and GSC groups was not statistically significant (interaction group effect) (p=0.24) (Table 2)

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