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Patients with NAFLD exhibit an increase in the activity of CYP2E1 and a diminution of 1.9 and 3.1 times in the activity of CYP3A4 in NAFLD and Non-alcoholic Steatohepatitis (NASH), respectively [80,81]

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Three principal amylin receptor subtypes exist [13] : AMY1 Receptor CTR + RAMP1 Primary receptor in area postrema (brainstem satiety center) [14] AMY2 Receptor CTR + RAMP2 Expressed in cardiovascular tissues and central nervous system [14] AMY3 Receptor CTR + RAMP3 Found in peripheral tissues including gastrointestinal tract [14] Cagrilintide binds to and activates these receptors with high affinity, triggering intracellular signaling cascades involving cyclic AMP (cAMP) and calcium mobilization [4]