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TongLuoYiShen formula consists of ten Chinese herbs, which can enhance the mRNA expression of Peroxisome proliferator-activated receptor- coactivator-1- (PGC-1), mitochondrial transcription factor A, restore the mitochondrial membrane potential, and promote mitochondrial biosynthesis in DN rats (65)

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If hematocrit exceeds 54%, stop therapy until hematocrit decreases to a safe level." [1] Whether Marek Health clinicians consistently apply this protocol is not externally auditable, but patients can self-assess by confirming their lab schedule matches this cadence