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However, in view of the excellent safety profile of B12, even at high doses, supplementation, ideally as part of a more comprehensive nutritional programme, may still be of value when the clinical picture and/or other factors (e.g

Supplement-driven elevations do not require worry in the vast majority of cases

Kidney Dysfunction: In chronic kidney disease (CKD) or renal failure, the bodys ability to filter and excrete B12 may be compromised, leading to accumulation in the blood 8